7013274
Description
Mind Map by Nicole Neumann, updated more than 1 year ago
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Created by Nicole Neumann
about 8 years ago
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HPV
- 8k bp circular DNA
- ORFs
- Early onset genes
- E1
- replicates viral episomes
- replicates viral episomes
- E2
- replication + transcription
- regulates E6/E7
- replication + transcription
- E4
- Viral maturation + release
- Viral maturation + release
- E5
- host cell proliferation
- inhibits immune response?
- host cell proliferation
- E6
- p53 inactivation
- uncontrolled cell cycle
- uncontrolled cell cycle
- p53 inactivation
- E7
- pRB inactivation
- uncontrolled cell cycle
- E7+pRB => E2F
- p16INK4
- ICC biomarker
- ICC biomarker
- p16INK4
- uncontrolled cell cycle
- pRB inactivation
- E1
- Late onset genes
- L1
- major capsid protein
- major capsid protein
- L2
- minor capsid protein
- minor capsid protein
- L1
- Early onset genes
- ORFs
- HPV types
- high risk
- HPV 16
- dominates 57% total
- dominates 57% total
- HPV 18
- 16% SCC
- dominates AdCA
- 16% SCC
- HPV 16
- low risk
- HPV 6 & 11
- HPV 6 & 11
- host cell DNA integration
- persistent HPV infection
- mutations
- mutations
- host cell DNA polymerase
- persistent HPV infection
- high risk
- HPV vaccine
- Gardasil & Cervarix
- cross immunity
- virus like particles
- type specific
- type specific
- L1 origin
- Gardasil & Cervarix
- CIN
- CIN1
- 1/3 N/C
- superficial/intermediate
- 1/3 N/C
- CIN2
- 2/3 N/C
- intermediate/parabasal
- medium clustering
- medium clustering
- 2/3 N/C
- CIN3
- 2/3+ N/C
- parabasal/basal
- grapes
- clustering
- grapes
- 2/3+ N/C
- CIN1
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