PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone

Autocrine vs paracrine vs endocrine signalling: Autocrine = Acts on [blank_start]__________[blank_end]; Endocrine = Acts on [blank_start]__________[blank_end]; Paracrine = Acts on[blank_start]__________[blank_end];

Fill in the gaps

What does OPG do to RANKL?

What effect does Calcitonin have on Osteoblasts?

What effect does Calcitonin have on Osteoclasts?

What effect does CSF1 have on Osteoblasts?

What effect does CSF1 have on Osteoclasts?

OCN is a hormone involved in the regulation of glucose metabolism, which improves the sensitivity of target organs to insulin, thus improving glucose handling by the body. …and MAYBE stimulates insulin production/secretion. Still, OCN = ??

OCN is the most abundant [blank_start]__________[blank_end] in bone.

ADHR = ??

OOM = ??

ADHR and OOM are examples of what?

Mis-sense mutations in [blank_start]__________[blank_end] in ADHR patients at a furin consensus cleavage site results in a resistance to proteolysis.

FGF23 regulates [blank_start]__________[blank_end] concentrations in plasma. It’s secreted by osteocytes in response to low [above] or [blank_start]__________[blank_end] Vitamin D.

FGF23 acts on the kidneys, where it [blank_start]__________[blank_end] the expression of NPT2 (a Na-PO4 co-transporter in the proximal tubule). This leads to [blank_start]__________[blank_end] PO4 reabsorption (which results in [blank_start]__________[blank_end] excretion).