WBC disorders

Description

Medicine Mind Map on WBC disorders, created by rania khalil on 07/05/2017.
rania khalil
Mind Map by rania khalil, updated more than 1 year ago
rania khalil
Created by rania khalil over 7 years ago
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Resource summary

WBC disorders
  1. leukopenias
    1. neutropenia
      1. increased destruction
        1. Immune destruction
          1. overwhelming infections.
          2. decreased production
            1. Aplastic anemia
              1. cancer chemotherapy
            2. lymphopenia
              1. HIV
                1. Corticosteroids
                  1. Radiation
                    1. Autoimmune diseases (SLE)
                      1. Primary immune deficiency syndromes (SCID- Digeorge
                    2. leukocytosis (proliferative disorders)
                      1. reactive
                        1. Neutrophilic leukocytosis
                          1. Bacterial infections
                          2. Eosiniophilia
                            1. Type I hypersensitivity
                            2. Lymphocytosis
                              1. Viral infections
                                1. Drugs (phynetoin)
                                2. Monocytosis
                                  1. Chronic infections
                                  2. leukemoid reaction
                                  3. neoplastic
                                    1. Basophilia
                                      1. Chronic myeloproliferative disorders
                                      2. Lymphoid Neoplasms
                                        1. Hodgkin lymphoma
                                          1. Non Hodgkin lymphoma (NHL)
                                            1. Lymphocytic leukemia
                                              1. Plasma cell neoplasms; (multiple myeloma)
                                              2. Myeloid neoplasms
                                                1. Acute myeloid leukemia (AML)
                                                  1. Chronic myeloproliferative disorders (MPD):
                                                    1. Chronic myeloid leukemia (CML)
                                                      1. investigations
                                                        1. FISH
                                                          1. PCR
                                                            1. karyotyping
                                                              1. Bone marrow aspiration and biopsy
                                                              2. Insidious onset
                                                                1. Three stages
                                                                  1. Chronic Stage
                                                                    1. Accelerated Stage
                                                                      1. Blastic Stage
                                                                2. Slow progression
                                                                  1. treatment options
                                                                    1. leads to
                                                                      1. Uncontrolled proliferation of transformed cells
                                                                        1. Discordant maturation
                                                                          1. Escape from apoptosis
                                                                            1. Altered interaction with the cellular Matrix
                                                                        2. signs and symptoms
                                                                          1. spleenomegaly
                                                                        3. tyrosine kinase inhibitors
                                                                          1. interferon & radiation therapy
                                                                            1. chemotherapy
                                                                              1. bone marrow transplantation
                                                                        4. Polycythemia vera
                                                                          1. Myelofibrosis
                                                                            1. Essential thrombocythemia
                                                                            2. Myelodysplastic syndromes (MDS) (cytopenias )
                                                                            3. Histiocytic neoplasms
                                                                              1. Langerhans cell histiocytosis
                                                                          2. history taking
                                                                            1. signs and symptoms
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