PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone

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PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine almost 7 years ago
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Resource summary

Question 1

Question
Autocrine vs paracrine vs endocrine signalling: Autocrine = Acts on [blank_start]__________[blank_end]; Endocrine = Acts on [blank_start]__________[blank_end]; Paracrine = Acts on[blank_start]__________[blank_end];
Answer
  • Itself
  • Distant tissue
  • Nearby tissue
  • External organisms

Question 2

Question
Fill in the gaps
Answer
  • RANKL
  • RANK
  • OPG
  • CSF-1
  • Calcitonin
  • PTH

Question 3

Question
What does OPG do to RANKL?
Answer
  • Fuck all
  • Inhibits ligand-binding
  • Facilitates ligand-binding

Question 4

Question
What effect does Calcitonin have on Osteoblasts?
Answer
  • Inhibits Osteoblast activity
  • Fuck all
  • Ensures their precursor's survival

Question 5

Question
What effect does Calcitonin have on Osteoclasts?
Answer
  • Inhibits Osteoclast activity
  • Fuck all
  • Ensures their precursor's survival

Question 6

Question
What effect does CSF1 have on Osteoblasts?
Answer
  • Inhibits Osteoblast activity
  • Fuck all
  • Ensures precursor's survival

Question 7

Question
What effect does CSF1 have on Osteoclasts?
Answer
  • Inhibits Osteoclast activity
  • Fuck all
  • Ensures precursor's survival

Question 8

Question
OCN is a hormone involved in the regulation of glucose metabolism, which improves the sensitivity of target organs to insulin, thus improving glucose handling by the body. …and MAYBE stimulates insulin production/secretion. Still, OCN = ??
Answer
  • OsteoCalciN
  • OsteoCalcitoniN

Question 9

Question
OCN is the most abundant [blank_start]__________[blank_end] in bone.
Answer
  • Non-collagenous protein
  • Mineral
  • Collagenous protein
  • Neurotransmitter
  • Osteokine

Question 10

Question
ADHR = ??
Answer
  • Autosomal Dominant Hypophosphataemic Rickets
  • Adrenal Dominant Hypophosphataemic Rickets
  • Autosomal Dominant Hyperphosphataemic Rickets
  • Adrenal Dominant Hyperphosphataemic Rickets

Question 11

Question
OOM = ??
Answer
  • Oncogenic OsteoMalacia
  • Osteogenic OncoMalacia

Question 12

Question
ADHR and OOM are examples of what?
Answer
  • Phosphate-wasting disorders
  • Calcium-wasting disorders
  • Vitamin-D-wasting disorders
  • Vitamin-K-wasting disorders

Question 13

Question
Mis-sense mutations in [blank_start]__________[blank_end] in ADHR patients at a furin consensus cleavage site results in a resistance to proteolysis.
Answer
  • FGF23
  • Interleukin 6
  • Interleukin 15
  • FGF6

Question 14

Question
FGF23 regulates [blank_start]__________[blank_end] concentrations in plasma. It’s secreted by osteocytes in response to low [above] or [blank_start]__________[blank_end] Vitamin D.
Answer
  • Phosphate
  • OPG
  • OCN
  • Calcium
  • Vitamin D
  • High
  • Low

Question 15

Question
FGF23 acts on the kidneys, where it [blank_start]__________[blank_end] the expression of NPT2 (a Na-PO4 co-transporter in the proximal tubule). This leads to [blank_start]__________[blank_end] PO4 reabsorption (which results in [blank_start]__________[blank_end] excretion).
Answer
  • Decreases
  • Increases
  • Increased
  • Decreased
  • Increased
  • Decreased
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